منابع مشابه
An immune clock of human pregnancy
The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate that these adaptations are precisely timed, reflecting an immune clock of pregnancy in women delivering at term. Using mass cytometry, the abundance and functional responses of all major immune cell subsets were quantified in serial blood samples collected throughout pregnancy. Cell signaling-based Elastic Ne...
متن کاملT Lymphocyte Characteristics and Immune Tolerance During Human Pregnancy
To ensure a fruitful and healthy pregnancy, every maternal organ system needs to adapt to the novel physiological needs raised by the developing fetus. The maternal immune system is no exception. Since the conceptus is half of foreign origins, presenting paternal antigens, it is considered a semi-allograft to maternal immunity. Therefore, an immune tolerance must develop to avoid immunological ...
متن کاملInhibition of Immune System by an Immunosuppressive Factor from a Human Prostatic Carcinoma Cell Line (JCA-1)
Prostatic carcinoma is the most commonly diagnosed tumor among men over 40 which results in over 30,000 deaths each year in the United States. Previous studies indicated that tumor cell lines produce and release several growth regulatory factors into their condition media and so far a number of human tumor cell-derived suppressor factors have been isolated that affect normal immune functions. I...
متن کاملCircadian Clock Mutation Disrupts Estrous Cyclicity and Maintenance of Pregnancy
Classic experiments have shown that ovulation and estrous cyclicity are under circadian control and that surgical ablation of the suprachiasmatic nuclei (SCN) results in estrous acyclicity in rats. Here, we characterized reproductive function in the circadian Clock mutant mouse and found that the circadian Clock mutation both disrupts estrous cyclicity and interferes with the maintenance of pre...
متن کاملCorrecting for purifying selection: an improved human mitochondrial molecular clock.
There is currently no calibration available for the whole human mtDNA genome, incorporating both coding and control regions. Furthermore, as several authors have pointed out recently, linear molecular clocks that incorporate selectable characters are in any case problematic. We here confirm a modest effect of purifying selection on the mtDNA coding region and propose an improved molecular clock...
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ژورنال
عنوان ژورنال: Science Immunology
سال: 2017
ISSN: 2470-9468
DOI: 10.1126/sciimmunol.aan2946